A Controlled Human Rhinovirus Infection Study of 2-Deoxy-D-Glucose in Healthy Adults

Inclusion Criteria: * Healthy male or female subjects 18 to 64 (inclusive at screening) years of age. * Women of childbearing potential and all males must practice effective contraception during the study and be willing and able to continue contraception until end of study. * Signed informed consent form prior to any study-related procedures. Exclusion Criteria: * Active smoker or history of smoking \> 5 pack years. * Upper or lower respiratory tract infection or febrile illness * Presence (at screening) of serum RV-39 neutralizing antibody titer at greater than one in four (1:4) dilution. * Nasopharyngeal swab indicative for Influenza or SARS-CoV2 infection by rapid antigen test at baseline. * Prior inoculation with a virus from the same virus family as the challenge virus. * Any anatomic or neurologic abnormality impairing the gag reflex, or associated with an increased risk of aspiration, or any abnormality significantly altering the anatomy of the nose or nasopharynx in a substantial way that may interfere with the aims of the study and in particular any of the nasal assessments or viral challenge. * Positive Hepatitis B surface antigen (HBsAg), Hepatitis C virus antibody (HCV Ab), or human immunodeficiency virus antibody (HIV Ab) at screening. * Any confirmed or suspected disease or condition associated with immune system impairment, including auto-immune diseases, asplenia or recurrent severe infections. * Active allergic rhinitis or hay fever. * Medical history or a…