RecruitingNot Applicable

Combination of Neurostimulation and Psychotherapy to Stop Worrying

Belgium85 participantsStarted 2024-03-06

Plain-language summary

This study aims to investigate whether the combination of transcranial Direct Current Stimulation (tDCS) and cognitive-behavioral therapy (CBT) is more effective for treating repetitive negative thinking (RNT) in patients with the symptom of high rumination. High ruminators will be included (Group1, active tDCS-CBT group; Group2, sham tDCS-CBT group). All patients will receive active or sham tDCS.

Who can participate

Age range18 Years – 70 Years

SexALL

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Inclusion Criteria: * Generalized anxiety disorder (GAD) * Depressive disorder Exclusion Criteria: * other psychiatric pathology than GAD or depression screened by senior psychiatrist by means of the Mini-International Neuropsychiatric Interview (MINI) and psychiatric anamnesis * Abuse of alcohol, drugs or medication other than prescribed by general practitioner or psychiatrist * no consent to participate in measurement (questionnaire, fNIRS or EEG) * Insufficient knowledge of the current language (Dutch) * Acute or chronic suicidality * Acute psychosis or manic depressive disorder * Inability to commit to 8 sessions of Cognitive-Behavioral Therapy (CBT) or receive 4 weeks of transcranial Direct Current Stimulation (tDCS).

What they're measuring

the therapeutic effect of the combination therapy for repetitive negative thinking

Timeframe: Baseline, up to 7 weeks' therapy and up to 3 months' therapy

the consolidation effect of tDCS on CBT

Timeframe: up to 7 weeks' therapy and up to 3 months' therapy

Trial details

NCT IDNCT06369532

SponsorUniversity Hospital, Ghent

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-09-26

Contact for this trial

Chris Baeken

+32476209841 Chris.Baeken@ugent.be