Estrogen Deficiency on Cardiovascular Risk

Inclusion Criteria: * Age 54-75 years * Healthy participants who are capable of giving informed consent * Classified as postmenopausal or stop having period \>1year or had a full hysterectomy surgery * Any race or ethnicity * Have satisfactory history and physical exam * Free of acute medical conditions Exclusion Criteria: * \<54 or \>75 years * Medications that could alter cardiovascular, thermoregulatory, or peripheral vascular control (e.g. Angiotensin converting enzyme inhibitors, statins, beta blockers, etc.); * Self-reported history of long-term menstrual irregularities, vaginal bleeding, or other gynecological conditions that could influence study outcomes * Use of hormone therapy during 6 months prior to study enrollment * Allergy to latex * Current smoker * Have any clinically relevant history or the presence of metabolic (e.g., diabetes), respiratory, renal, hepatic, gastrointestinal, hematological, lymphatic, neurological, cardiovascular, or other disease or diseases that, in the opinion of the research team, exclude the subject from participation. * Presenting with a resting blood pressure of 150/100 or higher * Contraindications to a maximal exercise test or an indication for early termination of an exercise test * Taking any medications that affect vascular control or autonomic function (e.g. beta blockers, ACE inhibitors, calcium channel blockers, etc.) * Contraindications to estrogen patch: include undiagnosed vaginal bleeding; known, suspected, or history …