CompletedNot Applicable

Perioperatively Assessed Biomarker I-FABP Level for Prediction of Acute Mesenteric Ischemia and Its Correlation With Acute Kidney Injury, Followed by Extracorporeal Circulation (aMIKI)

Germany500 participantsStarted 2022-03-01

Plain-language summary

Acute mesenteric ischemia (AMI) is a severe condition that might occur after cardiovascular surgery. Several risk factors for AMI, such as multimorbidity, the use of vasopressors, and an increase in inflammatory markers have been identified in the past. However, these risk factors also seem to influence the blood and urine levels of I-FABP. This prospective pilot study intends to evaluate the value of perioperatively assessed I-FABP levels and to correlate these values with clinical or angiographic findings in mesenteric ischemia to improve a standardised diagnosis.

Who can participate

SexALL

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Inclusion Criteria: * All consecutive patients undergoing cardiac or vascular surgery with extracorporeal circulation Exclusion Criteria: * endocarditis or bacterial sepsis, * hepatitis or HIV on the patient\'s medical history, * cases in which informed consent to participate in the study could not be obtained

What they're measuring

Concentration of I-FABP values with/and without acute mesenteric ischemia

Timeframe: 24 hours before and 36 hours after surgery

Trial details

NCT IDNCT06365827

SponsorUniversity of Giessen

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2023-12-31

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