The Safety and Efficacy Study of Ethylenediaminetetraacetic Acid (EDTA) Ophthalmic Solution in Patients With Loss of Contrast Sensitivity Due to Age-Related, Low-Grade Nuclear Cataract

Inclusion Criteria: * Male or female patients ≥ 50 years of age * Presence of early nuclear sclerosis cataract in both eyes below the level recommended for surgical replacement * Both eyes having contrast sensitivity measurements of: * Screening Visit: * Less than or equal to 6, 4 and 4 in spatial frequencies C, D and E, respectively under mesopic illumination * Baseline Visit: * Less than or equal to 6, 4 and 4 in spatial frequencies C, D and E, respectively under mesopic illumination and * Greater than 0 in all five spatial frequencies (Patches A, B, C, D and E) under photopic illumination * Best-Corrected Distance Visual Acuity (BCDVA) measurement by ETDRS of better than or equal to 20/50 in both eyes attributable to low- grade nuclear cataract * Patient must be willing and able to provide written informed consent * Patient must be willing and able to comply with study visits as described in the protocol Exclusion Criteria: * Clinical evidence of any active ocular infection (i.e., bacterial, viral, parasitic or fungal) in either eye * History of herpetic ocular infection in either eye * Presence or history of glaucoma in either eye * Presence or history of intraocular pressure of \>22 mm Hg in either eye * Amblyopia in either eye * Presence of any corneal disorder including pterygium or superficial keratitis * Dry eyes which require the use of a prescription medication * Presence of posterior subcapsular cataract * Presence of cortical cataract that intrudes …