Saliva Testing for High-Risk Human Papillomavirus Infection Oral Cavity and Pharynx Cancer

Inclusion Criteria (Patients with Cancer); * Patients must have histologically confirmed oropharyngeal squamous cell carcinoma without prior treatment. A pathology report should be referenced/available. * Patients with p16 positive oropharyngeal squamous cell carcinoma. * Age 39 to 59 years. * Ability to understand and the willingness to sign an IRB-approved informed consent document directly. Inclusion Criteria (Healthy Subjects) * Age 39 to 59 years. * Ability to understand and the willingness to sign an IRB-approved informed consent document directly. Exclusion Criteria (Patients with Cancer) * Patients with diagnoses of other cancers. * Patients with current or previous diagnosis with HPV+ infection status for cervical cancer or other cancers. Exclusion Criteria (Healthy Subjects) * Previous diagnosis of cervical cancer or other cancers. * Presence of known active oral infections of viral, fungal, or bacterial etiology except for gingivitis, periodontitis, or periapical abscess. Participants with known gingivitis, periodontitis, or periapical abscess are included.