The purpose of this study was to evaluate the safety and immunogenicity of a single intramuscular (IM) injection of different formulations of Quadrivalent Influenza Vaccine (QIV) messenger ribonucleic acid (mRNA) (MRT5421, MRT5424, and MRT5429) compared to an active control (QIV- standard dose (SD), QIV- high dose (HD) \[adults ≥ 65 years of age only\], or quadrivalent recombinant influenza vaccine (RIV4)) in adults 18 years of age and older.
Age range
18 Years
Sex
ALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Number of Participants With Immediate Unsolicited Systemic Adverse Events (AEs) After Vaccine Administration
Timeframe: Within 30 minutes after vaccine administration on Day 1
Number of Participants With Solicited Injection Site Reactions After Vaccine Administration
Timeframe: Within 7 days after vaccine administration on Day 1
Number of Participants With Solicited Systemic Reactions After Vaccine Administration
Timeframe: Within 7 days after vaccine administration on Day 1
Number of Participants With Unsolicited Adverse Events After Vaccine Administration
Timeframe: Within 28 days after vaccine administration on Day 1
Number of Participants With Medically Attended Adverse Events (MAAEs)
Timeframe: Within 180 days after vaccine administration on Day 1
Number of Participants With Serious Adverse Events (SAEs) and Adverse Event of Special Interest (AESIs)
Timeframe: From the vaccine administration (Day 1) until 12 months after vaccine administration, approximately 366 days
Number of Participants With Abnormal Biological Test Results
Timeframe: Within 8 days after vaccine administration on Day 1
Geometric Mean of Hemagglutination Inhibition (HAI) Antibody (Ab) Titer at Day 1
Timeframe: Day 1
Geometric Mean of Hemagglutination Inhibition Antibody Titer at Day 29
Timeframe: Day 29
Percentage of Participants With Detectable Hemagglutination Inhibition Antibody Titer >=1:10 at Day 1
Timeframe: Day 1
Percentage of Participants With Detectable Hemagglutination Inhibition Antibody Titer >=1:10 at Day 29
Timeframe: Day 29
Geometric Mean Ratio of Hemagglutination Inhibition Antibody Titer at Day 29
Timeframe: Days 1 and 29
Percentage of Participants With Seroconversion of Hemagglutination Inhibition Antibody Titer at Day 29
Timeframe: Day 29
Percentage of Participants With Hemagglutination Inhibition Antibody Titer >=1:40 at Day 29
Timeframe: Day 29
Percentage of Participants With >=2 and >=4 Fold Increase in Hemagglutination Inhibition Antibody Titer at Day 29
Timeframe: Days 1 and 29