CompletedNot Applicable

Infective Complications in TP Biopsy Without Antibiotic Prophylaxis

Hong Kong1,753 participantsStarted 2024-08-04

Plain-language summary

This study is a prospective cohort study to delineate the infective outcomes and incidence after transperineal prostate biopsy with no antibiotic prophylaxis, compared to the existing data on outcomes on patients receiving transperineal prostate biopsy with antibiotic prophylaxis.

Who can participate

Age range

18 Years

Sex

MALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * All consecutive patients in participating centres receiving transperineal USG-guided biopsy for any indication including: * Elevated PSA * Abnormal DRE * Follow-up biopsy in active surveillance * Suspicion of CAP recurrence after radiotherapy * Follow-up biopsy after focal therapy * Consenting to the study Exclusion Criteria: * Recent suspected UTI within 1 month * Recent culture proven bacteriuria within 1 month * History of recurrent UTI * Indwelling urinary catheter * Immunocompromised state * High risk of infective endocarditis (including prosthetic heart valve, congenital heart disease, or previous history of infective endocarditis * Incompetent or incapable of understanding the nature of the study or giving informed consent

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

The difference in UTI hospitalization rate between the two groups after biopsy

Timeframe: Within 14 days of biopsy

The difference in urosepsis rates between the two groups after biopsy

Timeframe: Within 14 days of biopsy

Trial details

NCT IDNCT06359964

SponsorChinese University of Hong Kong

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-03-13

View on ClinicalTrials.gov More Prostate Cancer trials