Assessing Repeatability and Intra-individual Variability in [O15]H2O-PET Myocardial Perfusion Ima… (NCT06356857) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Assessing Repeatability and Intra-individual Variability in [O15]H2O-PET Myocardial Perfusion Imaging
Denmark20 participantsStarted 2024-04-15
Plain-language summary
This study wish to assess the reproducibility of baseline and hyperemic myocardial blood flow as well as myocardial blood flow reserve measurements with \[O15\]H2O-PET-MPI.
Who can participate
Age range50 Years
SexALL
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Inclusion Criteria:
* Patients \> 50 years of age referred for \[O15\]H2O-PET-MPI by the dept. of cardiology on clinical indication with symptoms suggestive of myocardial ischemia, primarily angina.
* Willing to repeat the \[O15\]H2O-PET-MPI
* Normal left ventricular ejection fraction (EF \> 45), as assessed from recent (max 1 year old) echocardiography description in medical journal.
Exclusion Criteria:
* Cardiovascular event in between scans (defined as hospitalization for cardiovascular event).
* History of myocardial infarction
* Regional perfusion deficits on the primary \[O15\]H2O-PET-MPI clinically suspected as a sign of significant coronary stenosis.
* Unstable angina
* Severe Chronic Obstructive Pulmonary Disease (COPD)
* Severe asthma
* Claustrophobia
* Acute illness
* Significant language barrier, estimated by the investigator not being able to understand the study information sufficiently.
What they're measuring
1
[O15]H2O-PET-MPI variability and repeatability coefficient estimated from 20 patients having [O15]H2O-PET-MPI done twice