Oropharynx (OPX) Biomarker Trial

Inclusion Criteria: * Age ≥ 18 years * Able to provide written consent * Groups 1-3: * Must undergo p16 staining on biopsy for enrollment * Patients with \< 70% of tumor cells positive for p16 will be considered p16 negative * Must undergo HPV16 family in situ hybridization (ISH) and/or RNA on biopsy or surgical specimen, unless amount of tissue is too small to have conclusive HPV ISH testing done on it * Willingness and intent to return in person to enrolling institution for follow-up (during the Active Monitoring Phase of the study) for at least 2 of the standard follow-up time points for a total of 3 time-points including pre-treatment. A participant who does not return in person to Mayo Clinic Rochester for every standard of care post-treatment follow up will not be considered deviating from the protocol * Group 4: * Clinical suspicion or histopathologic diagnosis of head and neck cancer or neoplasm * Primary salivary neoplasm * Primary thyroid neoplasm * Primary head and neck neoplasm * Multi-cancer early detection (MCED) testing concerning for cancer * Patient has given permission to give his/her tumor/tissue/blood/saliva sample for research testing * Ability to complete questionnaire(s) by themselves or with assistance * Primary language: English, Spanish, Arabic Exclusion Criteria: * Receiving any other investigational agent which would be considered as a treatment for the primary neoplasm. * Groups 1-3: * Other active malignancy ≤ 5…