CompletedNot Applicable

The Effect of Intravenous Versus Volatile Anesthesia on Postoperative Cognitive Dysfunction in Elderly Patients

South Korea154 participantsStarted 2024-02-14

Plain-language summary

The goal of this clinical trial is to compare the permeability of blood-brain barrier between the intravenous anesthesia group and the inhalation gas anesthesia group in the elderly patients undergoing surgery. The main questions it aims to answer are: * \[Is the permeability of blood-brain barrier between the intravenous anesthesia group and the inhalation gas anesthesia group in the elderly patients different?\] * \[Is the incidence of postoperative cognitive dysfunction between the intravenous anesthesia group and the inhalation gas anesthesia group different?\] Participants will be anesthetized with different categories of anesthetics. * Intravenous anesthetics * Inhalation gas anesthetics

Who can participate

Age range60 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * age equal to or older than 60 * american Society of Anesthesiologists (ASA) grade I to III * general anesthesia longer than 2 hours Exclusion Criteria: * history of dementia * history of schizophrenia, epilepsy, or Parkinson's disease * history of stroke or craniectomy * patient denial

What they're measuring

Concentration of serum S100B levels

Timeframe: before surgery, at the end of surgery, 4 hours after surgery, 1st day after surgery

Trial details

NCT IDNCT06353516

SponsorChung-Ang University Gwangmyeong Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-10-30

View on ClinicalTrials.gov More Postoperative Cognitive Dysfunction trials