Examining the Role of Tolerance on Dose-dependent Effects of Acute THC on Oculomotor and Cognitive Performance

Inclusion Criteria: * Inclusion criteria: Healthy non-treatment seeking adults (age 18 to 60, N = 40) who report * (a) infrequent cannabis use defined as at least one reported use in the past year with a negative THC urine toxicology at baseline, or * (b) report frequent cannabis use defined as \> 5 days per week for \> 1 year with a positive THC urine toxicology at baseline. These criteria were selected to target individuals with low and high-frequency cannabis use in order to examine the direct effect of tolerance on study outcome measures. Exclusion Criteria: * (1) meet DSM-V criteria for substance use disorders other than tobacco, cannabis, or caffeine, * (2) are currently receiving or interested in immediately receiving behavioral treatment or medication for cannabis cessation, * (3) current use of any medications that could affect study outcomes, * (4) test positive for drugs of abuse (other than cannabis) and/or breath alcohol test at study admission, * (5) have a current physical or mental illness judged by the study team to negatively impact participant safety or scientific integrity, * (6) are currently pregnant, planning to become pregnant in the next three months or are currently breastfeeding, * (7) have a history of clinically significant cardiac arrhythmias or vasospastic disease (e.g. Prinzmetal's angina), or (8) are currently enrolled in another clinical trial or have received any drug as part of a research study within 30 days of study participation.