Evaluating Changes in Skeletal Muscle Proteins Following Resistance Exercise and Single-Leg Disuse (NCT06350591) | Clinical Trial Compass
CompletedNot Applicable
Evaluating Changes in Skeletal Muscle Proteins Following Resistance Exercise and Single-Leg Disuse
Canada15 participantsStarted 2024-04-01
Plain-language summary
Skeletal muscle plays a critical role in supporting human health. Beyond its role in providing the force to move, skeletal muscle accounts for a large proportion of metabolic rate, glucose disposal, and amino acid storage. Skeletal muscle is dynamically regulated by environmental stimuli, such as loading (i.e., resistance training\]) and unloading (i.e., disuse atrophy) as well as the intake of essential amino acids (EAAs). However, the precise mechanisms that regulate skeletal muscle mass in response to various conditions (e.g., EAA supplementation, resistance training, and unloading) are not completely understood. Therefore, concerted efforts to better understand the mechanisms regulating skeletal muscle size are needed that aid in the development of therapeutic interventions to combat age, disease, and disuse related muscular atrophy.
Who can participate
Age range
18 Years – 30 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Females 18-30 years
* BMI between 18-28 kg/m2
* ≥2 days per week of structured exercise
* Generally healthy as assessed by medical and physical activity questionnaires
* Participants not currently pregnant
Exclusion Criteria:
* Any muscular, neurological, respiratory, or metabolic disease including diabetes
* Any form of cancer currently or in the last 5 years
* Bleeding disorders or antiplatelet / anticoagulation therapy
* Currently taking fish oils or within the last 6 months
* Currently taking any form of steroid or within the last 3 months
* Inability to attain magnetic resonance imaging scans
* Known irregular responses to physical activity (e.g., shortness of breath, chest pain, dizziness, etc.)
* Any current illness
* Currently smoking or smoking within the last 6 months
* Currently pregnant
* Any concurrent medical, psychiatric, or orthopedic condition that, subject to investigators' discernment, would negatively affect the subject's ability to comply with the study requirements
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Changes in average rates of muscle synthesis
Timeframe: -2, 0 (-4, 0, and 4 hours), and 10 days