AUTOP 2: Screen-and-treat Strategy for Vaginal Flora Abnormalities by Molecular Biology in Pregnant Women at High Risk of Preterm Birth

* Pregnant woman over 18 years of age; * Single intra uterine pregnancy after 8 weeks and before 18 weeks of gestation (i.e. ≥ 8 weeks and ≤ 18 weeks). Woman can present symptomatic vaginal discharge, or can be asymptomatic or symptomatic with regard to the diagnosis of bacterial vaginosis (BV) with usual technics; * With a history of : * preterm birth before 37 weeks of gestation (even if the preterm birth was following preterm rupture of membranes); * and / or late miscarriage or fetal loss (i.e. miscarriage or foetal loss between 14 and 22 weeks of gestation), even if one any of her last birth occurred at term. * Woman having a reliable connexion by phone * Woman who has understood the study process and objectives and agreed to sign an informed consent form; * affiliated to a social security regimen or equivalent. Any eligible woman who will agree to participate in the study after being invited must sign a consent form before being included in the study. Women meeting all of these eligibility criteria will be invited even if they have oral or vaginal progestative treatment, cerclage or pessary, partially septate or arcuate uterus. Exclusion Criteria: * \- Woman of legal age under legal protection; * Women deprived of their freedom for administrative or legal reasons; * Woman who has not signed a consent form * Nulliparous; * Ectopic pregnancy; * Non-evolutive pregnancy or IUFD * Multiple pregnancy * Serious fetal malformation identified at first trimester screening…