Tacrolimus Exposure in Kidney Transplantation

Inclusion Criteria: * Renal transplant recipients between January 1, 2005 through December 31, 2014 in one of the five participating centers * Patients receiving oral tacrolimus as one of the main immunosuppressant at the start of the defined cohort time (i.e. at post-transplant 2 months for the analysis of 1-year outcomes and at post-transplant 12 months for the analysis of 6-year outcomes) Exclusion Criteria: * Graft failure occurring within the first 2 month of transplantation * Mortality of any cause occurring within the first 2 month of transplantation * Patients moving centers during the study period * Patients who have received other organ transplantation(s) besides renal transplantation in the defined period