CompletedNot Applicable

Sex Hormones and Inflammatory Biomarkers in Patients With Sickle Cell Disease

United States52 participantsStarted 2024-03-01

Plain-language summary

This study aims to characterize sex differences in the pathophysiology of vaso-occlusive crises (VOC) occurring among individuals with sickle cell disease (SCD). * The study will compare CRP and other biomarkers between females with SCD in the follicular phase of the menstrual cycle and males with SCD. * The study will explore potential sex differences in biomarker changes between females and males with SCD during and following resolution of VOC. * The study will compare neutrophil and platelet adhesion to the endothelium and real time fibrin deposition in the blood.

Who can participate

Age range18 Years – 45 Years

SexALL

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Inclusion Criteria: * Adult males and females aged 18-45 * Diagnosis of sickle cell disease * current hospitalization for vaso-occlusive pain episode or current outpatient infusion at the recruiting sites * Able to read and understand English * Willing to comply with study procedures Exclusion Criteria: * Currently pregnant, pregnant within the last month, or seeking to become pregnant

What they're measuring

C-reactive protein level

Timeframe: 1 month

Trial details

NCT IDNCT06345638

SponsorUniversity of Pennsylvania

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-06-17

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