Impact of Eccentric Training in Hypoxia With Creatine on Metabolic Control and VO2max in Patients With Type 1 Diabetes

Inclusion Criteria: * type 1 diabetes of at least 10 years duration, * low physical activity, * BMI:20-31 kg/m2, * treated with multiple insulin injections (at least 4 daily) or insulin pump (continuous subcutaneous insulin infusion \[CSII\]), * negative ECG exercise test, * HbA1c ≤ 8,0%, * high knowledge about functional insulin therapy, carbohydrate counting and diabetes management during exercise, * experience in use of FreeStyleLibre2 (Flash Glucose Monitoring System, Abbott), * Informed consent to participate in research signed by enrolled subjects Exclusion Criteria: * HbA1c \> 8,0%, * advanced complications of diabetes \[pre-proliferative or proliferative retinopathy, and previous laser therapy, microalbuminuria or overt nephropathy, autonomic neuropathy (including lack of elevated heart rate during physical activity)\], * patients physically active (regular physical activities more than once a week), * positive ECG exercise test, * history of cardiovascular event or coronary heart disease