CompletedNot Applicable

Metabolic Pathway Analysis in Intensive Care Unit Patients With Refeeding Syndrome

Czechia, Italy, Sweden218 participantsStarted 2024-04-01

Plain-language summary

The overall aim of the study is to improve understanding of refeeding syndrome (RFS) in patients admitted to the intensive care unit (ICU) using metabolomics. Patients are included as part of a prospective multicenter observational study on phosphate disorders in the ICU. Blood samples are collected day 1-7 of ICU stay. Samples from patients who develop refeeding hypophosphatemia and matched controls without hypophosphatemia are analysed for metabolomics and proteomics. Untargeted analyses will be performed to identify the affected metabolic pathways. The investigators will also perform AUROC analyses to identify potential biomarkers for early detection of RFS.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Admission to ICU during the study period * Age ≥18 years Exclusion Criteria: * Age \<18 years * Patients with restrictions of care such as "no intubation" or "no renal replacement therapy" on ICU admission and patients admitted for treatment as organ donors * Continuous chronic home ventilation for neuromuscular disease; * Declined participation or informed consent (if the local ethics committee requests the latter for this non-interventional study); * Readmission to ICU during the study period

What they're measuring

Metabolomics

Timeframe: Onset of RFS, within the first 7 days in ICU.

Trial details

NCT IDNCT06344546

SponsorKarolinska University Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-06-02

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