Active — Not RecruitingNot Applicable

Clinical Efficacy and Safety of Tender Point Infiltration (TPI) for Acute and Subacute Zoster Associated Pain

China136 participantsStarted 2025-06-01

Plain-language summary

Herpes zoster (HZ) is a skin infection disease which cause severe zoster-associated pain (ZAP) along sensory nerve in the corresponding segment. Evidence for the efficacy of existing local therapies for acute/subacute ZAP is limited. The hypothesis is that patients with acute/subacute ZAP treated with TPIs with local anesthetic and steroids under the basis of standard treatment will show better clinical outcomes compared with subjects treated with standard antiviral medicine treatment only.

Who can participate

Age range18 Years – 75 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Patients with onset of HZ rash less than 90 days.
✓. HZ affected the spinal nerves (cervical/thoracic/lumbar nerve).
✓. Aged 18 to 75 years (inclusive).
✓. Pain intensity \> 7 cm on a visual analogue scale (VAS 0-10 cm).
✓. Agreed to sign the informed consent form.

Exclusion criteria

✕. Infection at the puncture site.
✕. Poor general situation unable to be treated.
✕. A history of abuse of narcotics.
✕. Non-compliance or inability to complete the self-evaluation questionnaires.
✕. Pregnancy or lactation.
✕. Patients using immunosuppressants and those with severe systemic diseases such as hematological malignancies, cancers, or autoimmune disorders.

What they're measuring

The presence of postherpetic neuralgia using VAS score

Timeframe: 12 months

Trial details

NCT IDNCT06344403

SponsorBeijing Tiantan Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-10-01

View on ClinicalTrials.gov More Herpes Zoster trials