CompletedNot Applicable

The Effect of Active External Rewarming on Rewarming Rate in Simulated Prehospital Accidental Hypothermia

Norway11 participantsStarted 2024-05-28

Plain-language summary

In this study, we aim to compare the effect of active external rewarming to passive rewarming in healthy research participants on core temperature. The participants will be cooled to a core temperature of 35 degress C, the rewarmed using 2 different scenarios. Scenario 1 will be with passive rewarming, scenario 2 with active rewarming. Shivering will be pharmacologically inhibited using Buspirone and Meperidine.

Who can participate

Age range18 Years

SexALL

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Exclusion criteria

✕. Drugs: Concomitant use of sedatives, MAO-inhibitors, SSRI, ritonavir, cimetidine, chlorpromazine, phenytoin, erythromycin, itraconazole, platelet inhibitors, Apomorphine, alcohol (during the trial period) or other opioids or opioid antagonists (during the trial period). History of drug dependency.
✕. Recent head injury (last. 12 months), known increased ICP, seizures or epilepsy
✕. Other: Known reduced liver- or kidney function, reduced respiratory drive, known supraventricular tachycardia or prolonged QTc, hypertrophy of the prostate or urinary constriction, ongoing pregnancy or breastfeeding. Known acute glaucoma, myasthenia gravis. Previous abdominal surgery. History of cold injuries or frostbites.
✕. Planned MRI the next two days after ingestion of temperature capsule.

What they're measuring

Core body temperature

Timeframe: 2 hour cooling phase, 1 hour rewarming phase

Trial details

NCT IDNCT06342726

SponsorHaukeland University Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-06-02

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