Early Detection of Advanced Adenomas and Colorectal Cancer

Inclusion Criteria: * All individuals included in the study need to have had a colonoscopy at the time of blood sampling. * Received standard diagnostic and staging (as necessary) procedures as per local guidelines, and at least one sample was drawn before receiving any curative-intent treatment. * Received standard pathological and endoscopic diagnosis and assessment for cohort assignment. Exclusion Criteria: * Hereditary colorectal cancer syndromes (identified through genetic testing). * Inflammatory bowel diseases. * Lack of written informed consent.