Microvascular inflammation in kidney allografts has been widely reappraised in the recent update of Banff classification. There is a critical need to better understand the pathophysiological mechanisms associated with the various phenotypes of microvascular inflammation that are observed in kidney transplants, particularly in order to develop targeted therapeutic approaches.
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RNA-based molecular signatures assessed using bulk and spatial transcriptomics
Timeframe: 1 day (at time of a kidney allograft biopsy)
Probability of graft survival based on outcome data
Timeframe: 24 months post-kidney allograft biopsy
Probability of patient survival on outcome data
Timeframe: 24 months post-kidney allograft biopsy