Overall the study investigates organ crosstalk during exercise. More specifically, the study investigates the role of IL-6 in regulating glucose, fatty acid, and amino acid kinetics at whole body level and in skeletal muscle, liver, and brain. Furthermore, the study investigates the uptake and release of extracellular vesicles in skeletal muscle, liver, and brain in reponse to exercise.
Age range
18 Years – 45 Years
Sex
MALE
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Whole body substrate kinetics.
Timeframe: Comparisons between placebo and IL-6R ab are done at rest (time points 255 and 270 minutes), during exercise (time points 285, 300, 315, and 330 minutes) and during recovery from exercise (time points 345, 360, and 390 minutes).
Tissue specific utilization and production of substrates.
Timeframe: Comparisons between study arms are done at rest (time points 255 and 270 minutes), during exercise (time points 285, 300, 315, and 330 minutes) and during recovery from exercise (time points 345, 360, and 390 minutes).
IL-6 regulation of protein synthesis and degradation.
Timeframe: Comparisons between placebo and IL-6R ab are done at rest (time points 255 and 270 minutes), during exercise (time points 285, 300, 315, and 330 minutes) and during recovery from exercise (time points 345, 360, and 390 minutes).
Number of EVs from muscle, liver, and brain.
Timeframe: Comparisons between placebo and IL-6R ab are done before exercise (time points 255 and 270 minutes).
Size of EVs from muscle, liver, and brain.
Timeframe: Comparisons between placebo and IL-6R ab are done before exercise (time points 255 and 270 minutes).
EVs from muscle, liver, and brain.
Timeframe: Comparisons between placebo and IL-6R ab are done before exercise (time points 255 and 270 minutes).
Influence of exercise on EV number.
Timeframe: Comparisons between placebo and IL-6R ab are done throughout a 1-hour exercise bout (time points 285, 300, 315, and 330 minutes).
Influence of exercise on EV size
Timeframe: Comparisons between placebo and IL-6R ab are done throughout a 1-hour exercise bout (time points 285, 300, 315, and 330 minutes).
Influence of exercise on EV content.
Timeframe: Comparisons between placebo and IL-6R ab are done throughout a 1-hour exercise bout (time points 285, 300, 315, and 330 minutes).
Tissue specific proteomic content of EVs.
Timeframe: Comparisons between placebo and IL-6R ab are done at the end of a 1-hour exercise bout (330 minutes).