This clinical trial assesses differences in the delivery of THC to the bloodstream depending on whether nicotine vapes are used before or after THC. While there has been much recent publicity about vaping products and concern about their safety considering their increasing use for THC administration, the THC delivery profile associated with THC liquid vaping products in human subjects is currently unknown. Importantly, how the delivery to the bloodstream of THC vaping liquids compare to delivery from smoked cannabis, which is the most used method of cannabis delivery, will serve as an important benchmark for evaluating the delivery and effects of THC vaping products, and their relative safety.
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Maximum concentration of THC in plasma (Cmax)
Timeframe: Up to 21 days
Area under the plasma concentration-time curve from 0-360 minutes (AUC0-360)
Timeframe: Up to 21 days
Time to maximum concentration of THC in plasma (Tmax)
Timeframe: Up to 21 days