Pancreatic Cancer Screening in a Population at High Risk

Inclusion Criteria: * willing to participate in the study * age 18+ * arms specific criteria: A: * chronic pancreatic disease in the context of cystic fibrosis or chronic pancreatitis * age 50+ B1: * confirmed Peutz-Jegherson syndrome (mutSTK11) + age over 35 years or 10 years earlier than pancreatic ductal adenocarcinoma was diagnosed in the youngest family member * familial melanoma syndrome (mutCDKN2A) + age over 40 years or 10 years before pancreatic ductal adenocarcinoma was diagnosed in the youngest family member * confirmed hereditary pancreatitis (mutPRSS1) + age over 40 years or 20 years after the first attack B2: * confirmed diagnosis of hereditary syndrome (Lynch syndrome /mutMLH1, mutMSH2, mutMSH6, mutPMS2, mutEPCAM/, HBOC /mutBRCA1, mutBRCA2, mutPALB2, mutATM/, familial adenomatous polyposis /mutAPC/, Li-Fraumeni syndrome /mutTP53/) * at least one relative with a diagnosis of pancreatic ductal adenocarcinoma in family anamnesis at the same time (Grade I or II relative) * age over 50 years, or 10 years before the pancreatic ductal adenocarcinoma was diagnosed in the youngest relative - which comes first C: * positive family anamnesis of pancreatic ductal adenocarcinoma without hereditary syndrome context * age 50+ or 10 years earlier than the youngest relative with pancreatic ductal adenocarcinoma - screening is recommended for all first-degree relatives of affected family members Exclusion Criteria: * Inability to undergo radical curative surgery for a…