Active — Not RecruitingNot Applicable

Determination of Baseline Levels for Prostate Cancer-Derived Extracellular Vesicles Following Local Treatment of Prostate Cancer

United States98 participantsStarted 2020-06-10

Plain-language summary

This study is being done to determine whether levels of prostate cancer derived extracellular vesicles from blood and urine specimens correlate with response to primary local treatment (surgery) in prostate cancer.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * PROSTATE CANCER PATIENTS: * Age 18+ * Able to give informed consent * Patients with prostate cancer * Patients treated with primary prostatectomy * The focus will be on high-risk patients with at least one of either criterion: * PSA \>= 20 ng/ml * AND/OR Gleason \>= 8 * AND/OR clinical stage \>= T3 * FEMALE CONTROL PATIENTS: * Age 18+ * Able to give informed consent Exclusion Criteria: * PROSTATE CANCER PATIENTS: * Unable or unwilling to provide informed consent * Metastatic prostate cancer - defined evidence of metastatic disease on pre-procedural testing * FEMALE CONTROL PATIENTS: * Unable or unwilling to provide informed consent

What they're measuring

Levels of prostate cancer-derived extracellular vesicles (EVs) - radical prostatectomy

Timeframe: Pre-surgery; once post-surgery, 6 weeks to 6 months after surgery (likely collected during routine visits); annual blood collection (optional)

Levels of prostate cancer-derived extracellular vesicles (EVs) - negative controls

Timeframe: Baseline

Correlation between prostate specific antigen (PSA) levels and prostate cancer-derived EVs

Timeframe: Baseline

Prostate cancer-derived EV levels

Timeframe: Baseline

Trial details

NCT IDNCT06326216

SponsorMayo Clinic

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-12-01

View on ClinicalTrials.gov More Prostate Carcinoma trials

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Levels of prostate cancer-derived extracellular vesicles (EVs) - radical prostatectomy

Timeframe: Pre-surgery; once post-surgery, 6 weeks to 6 months after surgery (likely collected during routine visits); annual blood collection (optional)

Levels of prostate cancer-derived extracellular vesicles (EVs) - negative controls

Timeframe: Baseline

Correlation between prostate specific antigen (PSA) levels and prostate cancer-derived EVs

Timeframe: Baseline

Prostate cancer-derived EV levels

Timeframe: Baseline