Clinical and Immunological Evaluation of HA in Treatment of Periodontitis (NCT06324474) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Clinical and Immunological Evaluation of HA in Treatment of Periodontitis
Yemen24 participantsStarted 2025-04
Plain-language summary
To evaluate the immunological effectiveness of Hyaluronic acid as adjunction treatment to scaling and root planning and scaling and root planning alone.
Comparison between clinical measurement before and after treatment. Evaluate the level of IGF-1 in treated site as immunological marker if periodontal regeneration.
Who can participate
Age range
20 Years – 60 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* systemically healthy.
* at least 20 teeth and suffers from moderate \<7mm to severe. \>8mm.periodontitis with probing depth \>5m and in the contralateral side.
* ability to attend to the clinic in a regular manner.
Exclusion Criteria:
* allergy to HA.
* Chronic disease.
* orthodontic treatment.
* Qat chewer and smokers.
* antibiotic in previous 3 months.
* supplements and mouthwash.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Changes in Plaque Index
Timeframe: From Baseline to 12th weeks post intervention '' changes from baseline to 12th week"
2
Changes in Gingival Index
Timeframe: From Baseline to 12th weeks post intervention '' changes from baseline to 12th week"
3
Changes in Papillary Bleeding Index.
Timeframe: From Baseline to 12th weeks post intervention '' changes from baseline to 12th week"
4
Periodontal Probing Depth
Timeframe: From Baseline to 12th weeks post intervention '' changes from baseline to 12th week"
5
Clinical attachment loss
Timeframe: From baseline to 12th weeks post intervention "changes from baseline to 12th week
6
Changes in IGF-1
Timeframe: From baseline to 12th weeks post intervention "changes from baseline to 12th week