Cardiovascular Reactivity to Physical Stress (NCT06319001) | Clinical Trial Compass
CompletedNot Applicable
Cardiovascular Reactivity to Physical Stress
Norway45 participantsStarted 2024-02-19
Plain-language summary
It is well-accepted that an exaggerated blood pressure (BP) response to physical stress has a prognostic value, indicating a higher cardiovascular risk (e.g., sudden cardiac death, myocardial infarction, future hypertension, and left ventricular hypertrophy). However, there is a limited understanding of the underlying mechanisms and therapuetic strategies modulating this response. Therefore, this pilot project aims to explore whether one session of low-volume high-intensity interval training (low-volume HIIT) or combined intermittent heat and cold bath (sauna+cold bath) can decrease BP responses to physical stress. Furthermore, the secondary goal is to investigate whether one brief session learning about positive stress expectations magnifies the decrease in BP following low-volume HIIT and sauna+ cold bath.
Who can participate
Age range
18 Years – 50 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Male or female between 18 to 50 years
* Non-smoker.
* Non-obese (\<30 kg/m2).
* Able to walk on a treadmill and cycle on a stationary bike without problems.
* No or little (frequency \< 2 times per month) experience swimming with sauna and cold water.
* Proficient in Norwegian and able to provide informed consent.
Exclusion Criteria:
* Current or previous regular smoker
* Addictions to alcohol or illegal drugs
* Diagnosed with cardiovascular, respiratory, metabolic, or autoimmune diseases
* Taking prescription medication with known cardiovascular effects
* Judgment by a medical provider that exercise, heat therapy, or hydrotherapy poses an undue burden or risk.
* Cognitive or psychiatric impairment
* Lack of proficiency in Norwegian language oral or writing skills that will hamper the ability to participate in the interventions and fill out questionnaires.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Blood pressure (unit: mmHg) response to laboratory stressors
Timeframe: Assessment will be completed before intervention and approximately 30 minutes after intervention
Trial details
NCT IDNCT06319001
SponsorWestern Norway University of Applied Sciences