Effects of Perioperative Immunonutrition in Patients With Head and Neck Cancer

Inclusion Criteria: * Clinical diagnosis of squamous cell carcinoma of the oral cavity, oropharynx, larynx or hypopharynx who will undergo surgery, * who agree to receive standard EN or immunonutrition before surgery, * those between the ages of 18-75, * those with normal hematopoietic (absolute neutrophil count \>1.8x109/L, hemoglobin level ≥9 g/dL) hepatic and renal function Exclusion Criteria: * Patients receiving neoadjuvant chemotherapy or radiotherapy to the head and neck region; * Received EN support before the study * have an active infection, any autoimmune, renal or hepatic disease, malabsorption, type 1 diabetes or mental illness * taking vitamin-mineral supplements and immunosuppressive treatment, * Morbidly obese (BMI ≥40 kg/m2), HIV positive, pregnant and breastfeeding individuals