UnknownNot Applicable

GREM1, HAS2 and PTGS2 Gene Expression Following the in Vitro Maturation (IVM)

Malaysia30 participantsStarted 2021-07-01

Plain-language summary

Poor ovarian reserve (POR) is an adverse prognostic factor for In-Vitro Fertilization (IVF) success. Numerous established data showed low live birth rates per IVF cycle; 6 to 10%, including the usage of In-Vitro Maturation (IVM). In Malaysia, POR incidence increases mainly from cancer survival, endometriosis, and autoimmune diseases women; therefore, IVM implementation is paramount. In the molecular level, the low competence oocytes showed a low expression of GREM1, HAS2 and PTGS2 in human cumulus cells, thus leading to poor oocyte quality(OQ). Various IVM media had been formulated to enhance the competency and quality of the oocytes to date. Therefore, our study aims to elucidate the GREM1, HAS2 and PTGS2 gene expression as oocyte developmental competency markers among POR women following IVM and tailored to the IVF outcome.

Who can participate

Age range18 Years – 45 Years

SexFEMALE

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Inclusion Criteria: * women underwent IVF with normal and Poor ovarian reserve based on the Bologna criteria( anti-Müllerian hormone (AMH) below 0.5-1.1 ng/ml\]). Exclusion Criteria: * Male factor infertility (to reduce bias for embryo quality factor) * Not agree to participate.

What they're measuring

normal ovarian reserve

Timeframe: for 1 year duration

poor ovarian reserve

Timeframe: for 1 year duration

Trial details

NCT IDNCT06315777

SponsorNational University of Malaysia

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-07-01

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