CompletedNot Applicable

Predicting Local and Distant Recurrence in T1 Colorectal Cancer

United States, Japan, Spain138 participantsStarted 2023-03-15

Plain-language summary

Tumor recurrence significantly affects survival rates following the local resection of submucosal colorectal cancers (T1 CRC). Despite this, there are currently no reliable biomarkers established to predict recurrence in T1 CRC. This study seeks to improve the prediction of recurrence-free survival in individuals who have survived T1 CRC.

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: * Stage I, pT1 colorectal cancer (TNM classification, 8th edition). * Received standard diagnostic, staging, and stage-specific curative-intent resection (endoscopic or surgical, as per local guidelines). * Confirmed cancer-free survivorship at the time of study inclusion. Exclusion Criteria: * Lack of informed consent. * Induction of neoadjuvant systemic therapy before colorectal cancer resection. * Synchronous colorectal and non-colorectal cancer diagnosed at or before surgery.

What they're measuring

Recurrence-free Survival

Timeframe: Up to 60 months

Trial details

NCT IDNCT06314971

SponsorCity of Hope Medical Center

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-06-15

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