CompletedPhase 4

Clinical Evaluation of Hyaluronic Acid and Platelet Rich Fibrin Injection Efficacy in Interdental Papilla Reconstruction

Turkey (Türkiye)13 participantsStarted 2024-04-10

Plain-language summary

The goal of this clinical trial is to evaluate and compare the efficacy of injectable platelet rich fibrin (i-PRF) and hyaluronic acid (HA) in reconstruction of interdental papilla loss. The main questions it aims to answer are: * How compareable are above mentioned two interventions (i-PRF\&HA) in reconstruction of interdental papilla loss? * Which treatment option is better accepted by patients? Which treatment option would patients be more satisfied with? Participants with multiple interdental papilla loss will be treated with both i-PRF and HA in split-mouth design. Researchers will compare two treatment options to see if black triangles caused by interdental papilla loss closes and if yes, for how long do they last.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Systemically healthy (without cardiovascular diseases, diabetes, thyroid diseases, auto-immune diseases) * Patients with PPI 2 and PPI 3 papillae according to the Papillary Presence Index classification * Probable pocket depth of 4 mm or less in the relevant area * Plaque index and gingival index in the range of 0-1 * Neighbouring teeth in contact with each other in the relevant area * Absence of any restoration in the relevant area * Non-smoker * No surgical periodontal treatment in the last 6 months * For female subjects not pregnant or lactating * No known allergy to hyaluronic acid Exclusion Criteria: * Not systemically healthy (with cardiovascular diseases, diabetes, thyroid diseases, auto-immune diseases) * Diagnosed with periodontitis * History of allergic reactions to hyaluronic acid * Less than 2 mm keratinized tissue height in the relevant area * Teeth crowding in relevant area * Any kind of restoration (fillings, crowns, etc.) in the relevant area * Smoker * Ongoing orthodontic treatment * Having parafunctional habits (bruxism, etc.)

What they're measuring

Black Triangle Area

Timeframe: After the last injection: 1 month - 3 months

Intedental Papilla Reconstruction Rate

Timeframe: After the last injection: 1 month - 3 months

Trial details

NCT IDNCT06314256

SponsorAltinbas University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-06-01