Pharmacological Modulation of Peripheral Nerve Excitability
Denmark20 participantsStarted 2024-04-09
Plain-language summary
The present project is a human experimental study. The aim is to assess the pharmacologically modulated excitability of peripheral sensory nerves with a human experimental model.
The study measures the excitability of peripheral sensory nerves before and after application of different topical drugs (lidocaine (5%), phenytoin (10%),mepyramine (2%) and placebo).
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Men and Women age \> 18 years
* Understand and speak Danish
* No medication besides contraceptives
Exclusion Criteria:
* Pregnancy or lactating women
* Drug addiction (use of cannabis, opioids, or other drugs)
* Use of pain killers, alcohol, or nicotine within the last 24 hours before study start
* Any other medical treatment (e.g., antidepressants, anticonvulsants)
* History of peripheral or chronic pain conditions / neuropathy
* Skin diseases
* Scars and/or tattoos at the volar site of the forearm
* Previous traumatic experience of an electrical accident
* Application of moisturizing lotion of the volar site of the forearms (24 hours before study start)
* Participation in any other research projects/studies 7 days before study start
* Known allergy/intolerance to lidocaine/phenytoin/mepyramine
* Lack of ability to cooperate
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.