CompletedNot Applicable

Pharmacological Modulation of Peripheral Nerve Excitability

Denmark20 participantsStarted 2024-04-09

Plain-language summary

The present project is a human experimental study. The aim is to assess the pharmacologically modulated excitability of peripheral sensory nerves with a human experimental model. The study measures the excitability of peripheral sensory nerves before and after application of different topical drugs (lidocaine (5%), phenytoin (10%),mepyramine (2%) and placebo).

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Men and Women age \> 18 years * Understand and speak Danish * No medication besides contraceptives Exclusion Criteria: * Pregnancy or lactating women * Drug addiction (use of cannabis, opioids, or other drugs) * Use of pain killers, alcohol, or nicotine within the last 24 hours before study start * Any other medical treatment (e.g., antidepressants, anticonvulsants) * History of peripheral or chronic pain conditions / neuropathy * Skin diseases * Scars and/or tattoos at the volar site of the forearm * Previous traumatic experience of an electrical accident * Application of moisturizing lotion of the volar site of the forearms (24 hours before study start) * Participation in any other research projects/studies 7 days before study start * Known allergy/intolerance to lidocaine/phenytoin/mepyramine * Lack of ability to cooperate

What they're measuring

Change in PTT-value

Timeframe: 1 hour after application of cream

Trial details

NCT IDNCT06312254

SponsorAalborg University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-12-02

View on ClinicalTrials.gov More Peripheral Neuropathy trials