CompletedNot Applicable

Effect of Different Modalities of Cryotherapy on Post-Operative Pain in Patients With Symptomatic Irreversible Pulpitis

Egypt45 participantsStarted 2024-04-01

Plain-language summary

Problem statement: The post-operative pain after endodontic treatment. aim of study: The study is aiming to compare postoperative pain after submucosal cold saline injection (submucosal cryotherapy) (SMC) versus intra-canal cryotherapy (ICC) in mandibular single rooted premolars with symptomatic irreversible pulpitis with symptomatic apical periodontitis (SAP). The material and methods: Subjects and methods: sixty patients will be randomly divided into three groups: the SMC group, the ICC group, and the control group. The patients' postoperative pain will be recorded at 12, 24, and 48 hours postoperatively by questioning them. Quantification of substance P will be done using an ELISA test from peri-radicular fluid swab.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Older than age of 18 years * Participants willing to commit for the entire period of the trial and Both genders * agreed to sign the written consent after full explanation of the study * Having a mandibular single rooted premolar tooth with vital pulp * These patients were also suffering from symptoms of symptomatic irreversible pulpitis and apical periodontitis, intermittent or continuous sharp pain that lasts longer after removal of the stimulus. on the basis of the clinical symptoms of severe preoperative pain (visual analogue scale) Exclusion Criteria: * Vulnerable group; prisoners, pregnant females, mentally ill, etc… * Teeth with open apices * A previous root canal treatment * Sinus tracts * Presence of periodontal pockets \>3 mm in the affected tooth

What they're measuring

postoperative pain

Timeframe: After 12 hours

postoperative pain

Timeframe: After 24 hours

postoperative pain

Timeframe: After 48 hours

Trial details

NCT IDNCT06304259

SponsorOctober 6 University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-04-01

View on ClinicalTrials.gov More Endodontic Disease trials

Plain-language summary

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.