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Effect of Paracetamol and Mannitol Injection on Postoperative Analgesia in Patients With Thoracoscopic Lobectomy

90 participantsStarted 2024-03-15

Plain-language summary

This study thoroughly evaluates the efficacy of acetaminophen mannitol injection for postoperative analgesia in patients undergoing thoracoscopic lobectomy, by comparing it with a control group.

Who can participate

Age range18 Years – 60 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Obtain informed consent；
✓. Patients scheduled for partial lobectomy under thoracoscopy with general anesthesia；
✓. Classified as American Society of Anesthesiologists (ASA) physical status I\~II；
✓. Age over 18 years；
✓. Patients voluntarily participate and sign the informed consent form

Exclusion criteria

✕. Systolic blood pressure ≥180 mm Hg or \<90 mm Hg, diastolic blood pressure ≥110 mm Hg or \<60 mmHg
✕. heart rate \<50 beats/min；
✕. Patients with severe liver or kidney dysfunction (severe liver dysfunction: ALT, conjugated bilirubin, AST, ALP, total bilirubin any one \>2 times the upper limit of normal
✕. severe kidney dysfunction: creatinine clearance \<60 ml/min)；
✕. Patients with diabetes and complications (diabetic ketoacidosis, hyperosmolar coma, various infections, major vascular changes, diabetic nephropathy, retinopathy, diabetic cardiomyopathy, diabetic neuropathy, diabetic foot, etc.)；
✕. Patients with severe pulmonary impairment, such as asthma or chronic obstructive pulmonary disease；
✕. History of psychiatric illness or long-term use of psychiatric drugs, chronic pain medication, or history of alcohol abuse；
✕. Neuromuscular diseases；

What they're measuring

NRS scores

Timeframe: after extubation 10 (±5) minutes, before leaving the resuscitation room, 6 hours, 12 hours, 24 hours after surgery

RASS score

Timeframe: after extubation 10 (±5) minutes and 24 hours after surgery

Trial details

NCT IDNCT06304181

SponsorThe Fourth Affiliated Hospital of Zhejiang University School of Medicine

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-08-01

Contact for this trial

JianHong Xu

86-18867961109 xujh1969@163.com

View on ClinicalTrials.gov More Postoperative Analgesia trials