CompletedNot Applicable

Predictive Model for the Occurrence of Cerebral Vasospasm Complicating Subarachnoid Haemorrhage by Combined Analysis of the Kinetics of a Panel of Biomarkers.

France155 participantsStarted 2024-05-07

Plain-language summary

The objective is to create a dynamic clinical prediction model that includes routinely measured care and biological biomarkers to predict cerebral vasospasm within 14 days of bleeding in patients treated in the neurosurgical intensive care unit for subarachnoid hemorrhage. Patients admitted to intensive care will be followed for up to 14 days (D14 time horizon of interest), or until discharge from intensive care if earlier. Blood samples will be taken from D1 to D10 to isolate the blood biomarkers of interest for each patient. The measurement of biomarkers and cerebral vasospasm will be blinded to each other.

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: * Subarachnoid hemorrhage (of aneurysmal or non-aneurysmal etiology) less than 4 days prior to admission to neuro-resuscitation, diagnosed on clinical presentation and confirmed by brain imaging. * Free, informed and written consent signed by the patient (or, failing this, his or her representative). * Patient entitled to or affiliated with social security Exclusion Criteria: * Significant vasospasm on admission to the department, diagnosed on initial imaging * Patient whose short-term survival (48 hours) appears compromised * Contraindication to perfusion CT scan * Pregnant or breast-feeding women * Patient under legal protection (persons deprived of liberty or under guardianship)

What they're measuring

Occurrence of cerebral vasospasm

Timeframe: Day 14 after inclusion

Trial details

NCT IDNCT06303349

SponsorUniversity Hospital, Bordeaux

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-05-16