Negative Serology by Immunoenzymatic Test (EIA) in HIV-infected Children Treated Early With Antiretroviral in the ANRS-Pediacam Study: Pathophysiological Mechanisms

Inclusion Criteria: Case control study * Children included and followed in the ANRS 12225 study - Pediacam III * Having plasma samples in the bio bank during the above-mentioned periods Case:children with at least one negative HIV serology made by ELISA, permanent or transientduring follow-up. Control (4 groups) * HIV-infected children with positive serology and viral load (VL) \<400 copies /ml * HIV-infected children with positive serology and VL ≥400 copies / ml * HIV-uninfected children born to HIV-positive mothers * HIV-uninfected children born to HIV-uninfected mothers Selection of cases and controls will be matched on gestational age (premature \<37, term ≥37 weeks) and year of birth (2007-2008 and 2009-2010). Cross sectional study Inclusion criteria * All children still followed in the ANRS - Pediacam III cohort * Written consent of one of the parents or the guardian and assent of the child if aged ≥ 11 years and complete disclosure of HIV statusfor infected children for participation to the study. Exclusion Criteria: * Refusal by one of the parents or the guardian for the child's participation in the study * No assent of the child (if aged ≥ 11 years and with complete disclosure of HIV status, for infected children)