Profiling Microbiome Associated Metabolic Pathways in Oesophageal Cancer Survivors (NCT06302660) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Profiling Microbiome Associated Metabolic Pathways in Oesophageal Cancer Survivors
United Kingdom100 participantsStarted 2022-03-09
Plain-language summary
The goal of this observational study is to learn about long term symptoms in oesophageal cancer survivors. The main question it aims to answer is are:
* Study the changes in gut bacteria by examining saliva, stool and blood.
* Investigate the products of bacteria in breath to develop a non-invasive breath test to detect the changes in gut bacteria.
* Develop new strategies to treat this change and trial new treatments to improve quality- of-life in oesophageal cancer survivors.
Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of breath, saliva, blood, urine, stool and complete validated healthy-related quality-of-life questionnaires.
Researchers will compare symptomatic and asymptomatic participants to detect the changes stated above.
Who can participate
Age range
18 Years – 90 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Male and female patients aged 18-90 years
* Patients who underwent oesophagectomy for oesophageal adenocarcinoma with curative intent
* Disease free patients (CT with no evidence of recurrence within last 6 months or more than 5 years post oesophageal resection)
* Patients more than 1 year post oesophageal resection
Exclusion Criteria:
* Patients with Siewert III gastro-oesophageal junctional tumours
* Patients with evidence of disease recurrence
* Patients who are unable or unwilling to provide informed written consent
* Patients who have received antibiotic therapy within the last 4 weeks
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Identify microbiome dysbiosis in saliva associated with long-term functional symptoms.
Timeframe: 24 months
2
Identify microbiome dysbiosis in stool associated with long-term functional symptoms.