RecruitingNot Applicable

Inorganic Pyrophosphate Homeostasis (PPi) in Pediatric Chronic Kidney Disease

France60 participantsStarted 2024-05-27

Plain-language summary

The investigator aim to identify the role of inorganic pyrophosphate and other anti-calcifying molecules in vascular disease in children with chronic kidney disease, with a view to developing therapeutic approaches aimed at limiting the onset of vasculopathy.

Who can participate

Age range

0 Years – 18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: All groups : * Minor patients (\<18 years) * Patients of both sexes * Informed patients and parents who have signed the informed consent form * Patients affiliated to social security Control group : \- Patients with no particular pathology undergoing surgery and receiving a preoperative check-up CKD groups : * Patients on dialysis for more than 3 months, regardless of technique * Kidney transplant patients * Patients with CKD, whatever the cause Exclusion Criteria: * Progressive cancer or kidney disease * Treatments that may modify PPi concentration (e.g. bisphosphonates)

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Plasma pyrophosphate concentration [PPi]pl in children with CKD

Timeframe: 18 months

Trial details

NCT IDNCT06300788

SponsorCentre Hospitalier Universitaire de Nice

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-11-27

Contact for this trial

Julie BERNARDOR

04.92.03.63.65 bernardor.j@chu-nice.fr

View on ClinicalTrials.gov More Pyrophosphate, Fetuin A, IL1, IL6, TNFalpha, Control trials

Who can participate

Age range

0 Years – 18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.