Effect of Continuing Versus Holding Metformin During Hospitalizations. (NCT06296836) | Clinical Trial Compass
TerminatedPhase 4
Effect of Continuing Versus Holding Metformin During Hospitalizations.
Stopped: Low recruitment rate and an inability to meet power.
United States22 participantsStarted 2025-01-21
Plain-language summary
A randomized study of continuing versus holding metformin during hospitalizations to internal medicine services to determine the effects on glucose control, acidosis, abdominal symptoms, length of stay, and mortality.
Who can participate
Age range
18 Years – 110 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adult (18+ years of age)
* Admitted to an internal medicine service.
* On Metformin prior to admission.
Exclusion Criteria:
* Inability to take oral medications
* eGFR \< 30 ml/min/1.73 m2
* Dialysis
* Current Acidosis (pH \< 7.35) including diabetic ketoacidosis
* Child-Turcotte-Pugh class C hepatic cirrhosis
* Acute Decompensated Heart Failure
* Cognitively impaired and/or unable to consent
* Lack of or unwillingness to share contact information
* Pregnant women
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial was terminated before completing — do you know why it was stopped early, and does that affect whether continuing or holding metformin during a hospital stay is still considered safe for me?
2Since this was a Phase 4 trial looking at real-world use of an already-approved drug, what do we currently know from other evidence about whether it's better to keep taking metformin or pause it when I'm hospitalized with Type 2 diabetes?
3The trial was measuring mean glucose levels as its main outcome — based on what was collected before the study ended, is there any signal about how metformin use during hospitalization might affect blood sugar control that's relevant to my situation?
4If I were ever hospitalized, what is your standard practice for managing my metformin — would you continue it, hold it, or switch me to something else, and what factors would drive that decision?
5Are there other completed studies or clinical guidelines you'd rely on instead of this terminated trial to guide decisions about my metformin use if I need to be admitted to the hospital?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.