The purpose of this project is to improve our understanding of peripheral circadian rhythms in humans. Circadian clocks are present in most tissues of the body with importance for optimal physiological function, health, and behavior. This project will utilize simulated jetlag protocols to systematically test novel hypotheses about the regulation of peripheral circadian rhythms in humans. Specifically, we will examine how changes in the time of when we are exposed to light and the timing of when we eat impacts proteins in the blood and saliva that represent rhythms from clocks in the brain (e.g., rhythms of the hormones melatonin and cortisol coordinated by the brain) and rhythms from clocks in body tissues (e.g., proteins made by immune and bone cells, and cells in the stomach and liver). We also aim to discover new blood-based biomarkers of peripheral rhythms in humans. We anticipate our findings will be the first step in developing novel circadian based treatments for aligning peripheral clocks under conditions such as jetlag, and for developing novel circadian biomarkers that will advance our scientific understanding of circadian rhythms.
Age range
17 Years – 35 Years
Sex
ALL
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PYY
Timeframe: hourly for up to 25 hours on two occasions
Ghrelin
Timeframe: hourly for up to 25 hours on two occasions
Leptin
Timeframe: hourly for up to 25 hours on two occasions
CRP
Timeframe: hourly for up to 25 hours on two occasions
OMD
Timeframe: hourly for up to 25 hours on two occasions
PAI-1
Timeframe: hourly for up to 25 hours on two occasions
IgE
Timeframe: hourly for up to 25 hours on two occasions
CCL18
Timeframe: hourly for up to 25 hours on two occasions
PTH
Timeframe: hourly for up to 25 hours on two occasions