The Effects of Ischemic Conditioning in Individuals With Parkinson's Disease (NCT06293118) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
The Effects of Ischemic Conditioning in Individuals With Parkinson's Disease
34 participantsStarted 2026-10-01
Plain-language summary
Ischemic conditioning (IC) is a promising therapy that can mimic the physiological effects of physical exercise. IC consists of using a cuff to measure blood pressure and calibrate 200 mmHg on the upper or lower limb. Thus, at alternating intervals of 5 minutes, ischemia or reperfusion occurs, depending on whether the cuff is inflated or deflated. IC induces changes in spinal cord excitability for the last reflex reactions of recruited motoneurons with improved balance control in healthy young people and improved learning in the elderly. The objective of the present study is to evaluate the chronic effect of IC on the motor function and cognitive performance of patients with Parkinson's disease. Furthermore, the investigators will evaluate secondary outcomes such as mobility, quality of life, and immunological responses.
Who can participate
Age range
40 Years – 90 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* PD patients aged 40 years or older;
* Diagnosis of PD without cognitive complaints or with complaints, but without impact on daily activities;
Exclusion Criteria:
* Patients with uncontrolled diabetes mellitus or peripheral neuropathy;
* Uncontrolled arterial hypertension (BP\>160/100mmHg);
* Uncontrolled diabetes (Fasting glucose \> 250mg/dl, peripheral retinopathy or diabetic ketoacidosis);
* Uncontrolled dyslipidemia (total chol \> 220mg/dL);
* Pre-existing autoimmune diseases;
* Infectious conditions for less than 1 month;
* Neurological problems that prevent training from being carried out;
* History of anemia, cerebral vascular disease, myocardial infarction in the last 6 months;
* Previous deep vein thrombosis;
* Smoking \< 6 months;
* Symptomatic peripheral arterial obstructive disease;
* Cognitive dysfunction: Moca \< 24.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is testing 'ischemic conditioning' for Parkinson's disease — can you explain what that procedure actually involves physically, and whether there are any risks I should know about given my specific health history?
2The trial is measuring outcomes using the Unified Parkinson's Disease Rating Scale and the Montreal Cognitive Assessment, which cover both movement and thinking — does my current stage of Parkinson's make me a reasonable candidate for a study like this, or would standard treatments address those same areas more reliably right now?
3Since this trial is listed as 'not yet recruiting,' how would I find out when it opens, and is there any reason to wait for it rather than pursuing other treatment options in the meantime?
4This trial is listed as Phase NA, meaning it may be exploratory — what does that mean for how much is already known about whether ischemic conditioning is safe or effective for people with Parkinson's?
5Are there any standard or already-approved therapies that target the same motor and cognitive symptoms this trial is measuring, so I can compare what a proven option might offer versus participating in this study?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.