CompletedPhase 4

Mepivacaine vs Bupivacaine Spinal Anesthesia for TKA

United States138 participantsStarted 2024-02-16

Plain-language summary

This study is a prospective, double-blind prospective randomized controlled trial comparing mepivacaine and bupivacaine spinal anesthesia for same-day discharge readiness following a unilateral primary elective TKA procedure. Study data will be collected during the patient's hospital stay for their TKA procedure, and the primary outcome of same-day discharge readiness will be assessed the day of surgery. Patients will also be contacted at Day 3 post-op to assess for any complications, current level of pain, and pain medication utilization.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patient is at least 18 years of age who are scheduled for a primary elective TKA. * Patient can ambulate at least 10 feet independently without human assistance. * Patient must be a candidate for same day discharge as determined by American Society of Anesthesiologists (ASA) Physical Status Classification I and II Exclusion Criteria: * Patients scheduled for bilateral TKAs * Contraindication to spinal anesthesia * Revision TKAs * Allergy or contraindication to NSAIDs (e.g. chronic anti-coagulant use) * Workers' Compensation patient * Type I Diabetes * Type II Diabetes requiring insulin medication. * Pre-operative narcotics use with the exception of tramadol. * Renal insufficiency (GFR \< 60) that may impact post-operative protocol * Cognitive deficiencies that prevent the patient from providing their own informed consent * Language barrier preventing completion of study forms in English

What they're measuring

Same day discharge rate

Timeframe: 24 hours

Trial details

NCT IDNCT06291727

SponsorPrisma Health-Upstate

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-08-01