WithdrawnPhase 4

Azithromycin Reduction to Reach Elimination of Trachoma B

Stopped: Study withdrawn (no participants enrolled) due to resources.

Democratic Republic of the Congo0Started 2024-10

Plain-language summary

The investigators propose a randomized controlled trial of discontinuation versus continuation of annual mass azithromycin distribution in hypoendemic communities of Maniema, DRC. The investigators will randomize communities with up to 20% Trachomatous Inflammation - Follicular (TF) prevalence following at least 5 years of mass azithromycin distribution to discontinuation or continuation of 3 additional years of annual mass azithromycin distribution.

Who can participate

Age range1 Month – 9 Years

SexALL

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Inclusion Criteria: * Provision of appropriate informed consent * Stated willingness to comply with all study procedures * Live in one of the 80 communities with up to 20% prevalence of TF selected for the trial Exclusion Criteria: * Does not consent to participation * Unwilling to comply with all study procedures * Does not live in one of the 80 communities with up to 20% prevalence of TF selected for the trial

What they're measuring

Ocular chlamydia measured in a population-based sample of 0-9 year-old children

Timeframe: 36 months

Trial details

NCT IDNCT06289647

SponsorUniversity of California, San Francisco

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2029-08-31

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