CompletedNot Applicable

Analysis of Vitamin D and VDR Expression in Endometriosis: A Case-Control Study

Thailand108 participantsStarted 2024-05-06

Plain-language summary

The goal of this cross-sectional prospective matching study is to evaluate whether serum vitamin D levels and vitamin D receptor (VDR) expression are associated with the presence and severity of endometriosis in women of reproductive age. The main questions it aims to answer are: * Is there a difference in serum 25-hydroxyvitamin D \[25(OH)D\] levels between women with endometriosis and healthy controls? * Is there a correlation between serum vitamin D levels and VDR expression in endometriotic tissues? * Is there an association between vitamin D status and the severity of endometriosis based on the revised American Society for Reproductive Medicine (rASRM) staging? Researchers will compare participants with endometriosis to matched healthy controls (1:2 ratio). Participants will: * Provide blood samples for serum 25(OH)D measurement. * Undergo surgical tissue sampling (for the endometriosis group) to assess VDR expression using immunohistochemistry staining. * Complete structured questionnaires regarding sun exposure, lifestyle, and clinical characteristics.

Who can participate

Age range18 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria Endometriosis Group: * Women diagnosed with ectopic endometriotic tissue: * Have a scheduled surgery appointment at Sri Nakarin Hospital. * Are aged 18 years or older. Inclusion Criteria Control Group: * Women undergoing examination at the outpatient department of Sri Nakarin Hospital. * No history of gynecological diseases or previous treatment for gynecological conditions associated with lower abdominal pain, infections, or abdominal masses at present. * Have undergone a gynecological examination within the past year, or if examined during the current visit, the results were normal. * Have undergone an ultrasound examination within the past year, or if examined during the current visit, the ultrasound results were normal. Exclusion Criteria: * Received vitamin D supplements within the past 3 months prior to volunteering. * History of chronic infectious diseases. * Previously treated for autoimmune diseases. * History of polycystic ovarian. * History of bone disorders or receiving medications affecting bones. * Irregular menstrual cycles or absence of menstruation for more than 3 months up to 1 year.

What they're measuring

Vitamin D level

Timeframe: At enrollment

Trial details

NCT IDNCT06289257

SponsorKhon Kaen University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-12-23