Green Propolis Extract and Royal Jelly in Hypertensive Patients and/or With Chronic Kidney Disease

Inclusion Criteria: * patients in stages 3 and 5 of CKD (GFR from 15 to 59 mL/min), * patients receiving ambulatorial nutrition treatment at least 6 months * patients on regular Hemodialysis treatment for at least 6 months * patients using one to three antihypertensive drugs Exclusion Criteria: * autoimmune and infectious diseases, * diabetes * cancer * AIDS * pregnant women * patients using catabolic drugs or antibiotics; * patients with catheter access to hemodialysis; * patients using antioxidant vitamin supplements, prebiotics, probiotics, symbiotic, * Patients on regular intake of propolis who are allergic to corn starch or report being allergic to bee stings. * patients with acute myocardial infarction (AMI) and/or cerebrovascular accident (CVA)