CompletedNot Applicable

Alveolar-capillary Reserve After Exercise in Chronic Obstructive Pulmonary Disease (COPD) (COP-DTPA)

Denmark32 participantsStarted 2024-05-06

Plain-language summary

It is unknown whether individuals with COPD exhibit abnormal alveolar-capillary breaching during exercise, and whether this contributes to exertional dyspnoea. The aim of this study is to investigate whether individuals with COPD exhibit an abnormal increase in alveolar-capillary breaching during exertion, as indicated by an increase alveolar-capillary permeability with a concomitantly exacerbated increase in lung tissue mass.

Who can participate

Age range45 Years – 80 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria - individuals with COPD * Men and women * 45-80 years old * COPD (GOLD stage I to III) * Resting arterial oxygenation \> 90% Inclusion criteria - healthy controls * Men and women * 45-80 years old * Non-smokers * Normal lung function * Same sex, age (± 3 years) as the COPD group Exclusion criteria - individuals with COPD * Symptoms of ischemic heart disease * Known heart failure * Symptoms of illness, including fever, within 2 weeks prior to the study * Pregnancy * • Known renal or liver diseaseActive smoking (within 3 weeks) Exclusion criteria - healthy controls * Known chronic lung disease * Symptoms of ischemic heart disease * Known heart failure * Symptoms of illness, including fever, within 2 weeks prior to the study * Pregnancy * Known renal or liver disease * Active smoking (within 3 weeks)

What they're measuring

Rest-to-exercise pulmonary DTPA clearance change after exercise in COPD vs. controls

Timeframe: Measured at study day 2

Trial details

NCT IDNCT06287476

SponsorRigshospitalet, Denmark

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-05-02