UnknownNot Applicable

The Role of the Free/Pedunculated Flap in Total Laryngectomy After (Chemo-)Radiotherapy Failure for Laryngeal Carcinoma: Impact on the Risk of Pharyngocutaneous Fistula (PCF)

Italy102 participantsStarted 2023-03-21

Plain-language summary

Multicenter, prospective, randomized study aimed at evaluating the difference in risk of PCF after salvage laryngectomy in two groups of patients: one cohort treated with Total Laryngectomy (LT) with primary suture, a second group treated with LT and reinforcement by flap positioning with onlay technique (PMM, ALT)

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. pre (ChT-)RT staging: cT1/T2/T3 N0/N+;
✓. pre STL staging: rcT1/cT2/ Selected cT3 cT4a (extension to thyroid cartilage and/or prelaryngeal tissues) N0/N+ (clinically and radiologically).

What they're measuring

questionnaires for evaluation of the quality of life

Timeframe: 30 months

Trial details

NCT IDNCT06287034

SponsorRegina Elena Cancer Institute

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-03-21

Contact for this trial

Raul Pellini, Doctor

06-52664484 raul.pellini@ifo.it

View on ClinicalTrials.gov More Larynx Carcinoma trials