Removal Of CytoKines With cytoSorbenTs After Inflammatory Response Reaction During Cardiac Surgery

Inclusion Criteria: * planned cardiac surgical procedure with the use of the cardiopulmonary machine as well as with ECMO use (elective or urgent) * age at the time of surgery of \>18 years. * informed consent Exclusion Criteria: * An emergency indication; * endocarditis, a non-sterile inflammation, * autoimmune diseases, chronic inflammatory diseases (ankylosing spondylitis, psoriasis, rheumatoid arthritis, chronic inflammatory intestinal diseases), an acquired immune deficit (HIV); * severe liver dysfunction, hepatitis B/0; * patients on dialysis; * Patients with a hematopoietic disorder/tumour disease; * participation in other interventional trials or studies; * timely and probable follow-up cannot be guaranteed (e.g. due to long distances between home and study site); a pregnancy that cannot be excluded with certainty (no menopause, no sterilization).