CompletedNot Applicable

Esketamine vs Remimazolam for Postoperative Sleep Disturbance and Anxiety

China315 participantsStarted 2024-03-04

Plain-language summary

To explore and compare the effects of esketamine and remimazolam on postoperative sleep disturbance in patients undergoing oocyte retrieval

Age range18 Years – 45 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

✓. Age 18-45 years old;
✓. American society of Aneshesiologists（ASA）physical status classification system is grade I-III;
✓. Elective surgery is proposed
✓. BMI of 19-30 kg/m2;
✓. Patients who agreed to enroll in this study voluntarily

✕. Those who are known to be allergic to the drug ingredients in this study and their allergic constitution;
✕. Allergic history of general anesthesia drugs, opioid drugs, non-steroidal drugs;
✕. History of neurological diseases; History of chronic pain; Drug and alcohol addiction; A long history of opioid use; Opiates were given 48 hours before surgery
✕. Coronary heart disease, bronchial asthma, severe hypertension, severe blood system dysfunction, liver and kidney function, electrolyte abnormalities;
✕. Respiratory insufficiency, respiratory failure;
✕. BMI\<18 kg/m2 or BMI\>30kg/m2;
✕. Poor compliance, unable to complete the experiment according to the study plan; Participants who have participated in clinical trials of other drugs within the last 4 weeks;
✕. Preoperative Pittsburgh Sleep Quality Index (PSQI) higher than 7

The incidence of postoperative sleep disturbance on the first night after surgery

Timeframe: the first night after surgery

NCT IDNCT06284668

SponsorTianjin Medical University General Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-05-10